Matrix Effects in LC-MS: Simple Way to Monitor

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This post shares information on our work in the area of matrix effects.  Matrix effects in LCMS can affect sensitivity, precision and accuracy.  We have developed a simple way to monitor phospholipids and lysophospholipids which yield matrix effects.  This approach is easily used in developing MRM LC-MS-MS analyses.


I have attached several links on the internet including:

ASMS Poster Sessions:



Prepress of Journal Article:


A published copy of the article can be found at J. L. Little, M. F. Wempe, C. M. Buchanan, Journal of Chromatography B, 833 (2006) 219-230.

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