Identification of Silylation Artifacts in Derivatization Reactions

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Silylation Artifacts in Derivitization Reactions:  This post summarizes the identification of silylation artifacts from our laboratory and the literature.  Normally silylation derivatization reactions  give the desired derivative in high yields.

silylation_groups

However, sometimes artifacts (by-products) are formed.  The paper linked below lists all the types of artifacts noted in our laboratory in the last 20 years and ones we have found in the literature. It is a modified (not refereed) copy of a paper [J.L. Little, J. Chromatogr. A, 844 (1999) 1-22] containing additional examples found since the paper was published.

silyl_2014_text

General Review Articles on Derivitization:

Derivatization Methods in GC and GC/MS

DOI: dx.doi.org/10.5772/intechopen.81954
Serban C. Moldoveanu1* and Victor David2

MASS SPECTROMETRIC FRAGMENTATION OF TRIMETHYLSILYL AND RELATED ALKYLSILYL DERIVATIVES: MASS SPECTROMETRY OF TMS DERIVATIVES

DOI:10.1002/mas.21590
David John Harvey, Paul Vouros

Common Fragments Ions and Ions for Linear and Cyclic Siloxanes:

Handout from the NIST Mass Spectromety Data Center

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